Isozyme variations in liver acetaldehyde dehydrogenase(ALDH) in alcoholic and non-alcoholic liver diseases.

Acetaldehyde adducts in alcoholic liver disease

Chronic alcohol abuse causes liver disease that progresses from simple steatosis through stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition, chronic alcoholic liver disease (ALD), with or without cirrhosis, increases risk for hepatocellular carcinoma (HCC). Acetaldehyde, a major toxic metabolite, is one of the principal culprits mediating fibrogenic and ...

Impaired acetaldehyde metabolism in patients with non-alcoholic liver disorders.

In order to determine the specificity of abnormalities of alcohol metabolism in patients with alcoholic liver disease, blood acetaldehyde concentrations after oral ethanol challenge and the activities of alcohol metabolising enzymes in liver biopsy samples have been determined in patients with alcoholic liver disease and a wide variety of non-alcoholic liver disorders. Significant decreases in ...

Lifestyle in Non-alcoholic Fatty Liver: A Review

Background: The world is now in the process of passing on health to non-diseases chronic, like non-alcoholic fatty liver (NAFLD) is a major cause of changes in the lifestyle of people. This study aims to evaluate the effects of lifestyle on fatty liver disease (NAFLD). Methods: For this critical review, we identified articles by searching original studies and review articles published in peer ...

Alcoholic Hepatitis, Alcoholic Cirrhosis & Non-Alcoholic Fatty Liver Disease (NAFLD)

[Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis].

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...